about event

The conference will bring together researchers working in the areas of DNA damage, DNA repair, recombination, genomic instability, and cancer. Around 10 scientists from France and 15 scientists from India will participate in this meeting. Approximately 40 PhD students and postdoctoral fellows working in the area of Genome integrity and plasticity will also get the opportunity to attend the meeting and present their work. This meeting will be a unique opportunity to explore and establish new collaborations between Indian and French Scientists.

We look forward to your participation and a successful event.

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DAY 1: Monday, 4 December 2017




07:00 am – 08:15 am BREAKFAST
07:30 am – 08:30 am Registration
08:30 am – 08:50 am
08:50 am 10:40 am     Session I: DNA repair and recombination
  Chairperson: Pablo Radicella and  B.J. Rao
08:50 am – 09:20 am

IL 1: J. Pablo Radicella, IRCM, Fontenay aux Roses

Cohesin and Mediator are required for the initiation of base excision repair in the nucleus
09:20 am – 09:50 am

IL 2: B. J. Rao, TIFR, Mumbai

Genetic cross-talk between DNA damage signalling and apoptosis regulates tissue homeostasis in D. melanogaster
09:50 am – 10:20 am

IL 3: Utpal Tatu, IISc, Bangalore

A novel, post-transcription repair process for expression of a split Hsp90 gene in Giardia lamblia
10:20 am – 10:40 am

SP 1: Krishna Murari Sinha, Amity University, Gurgaon

Role of cyclic di-AMP in regulating RecA expression and activity in Mycobacterium
10:40 am – 11:10 am COFFEE BREAK and Conference Photograph

11:10 am  01:00 pm                                                

Session II: Nonhomologous end joining: Mechanism and therapeutic implications    

  Chairperson: Mauro Modesti and Sathees C. Raghavan
11:10 am – 11:40 am

IL 4: Mauro Modesti, CRCM, Marceille

Dynamics and mechanics of DNA tethering by core c-NHEJ factors and by the MRE11/RAD50/NBS1 complex
11:40 am – 12:10 pm

IL 5: Jean-Pierre de Villartay, INSERM, Paris

DNA double strand breaks in the Immune System: a dangerous game
12:10 pm – 12:40 pm

IL 6: Sathees C. Raghavan, IISc, Bangalore

Inhibitors of Nonhomologous DNA End joining in Cancer Therapy
12:40 pm – 01:00 pm

SP 2: Sheetal Sharma, IFOM, Milan

DNA damage sensors Mre11-Rad50-Nbs1 and KU70/80 are required for Transcriptional Initiation from DNA Double-Strand Break Ends
01:00 pm – 01:50 pm LUNCH BREAK
01:50 pm – 03:50 pm     Session III: Genome integrity and plasticity in bacteria
  Chairperson: V. Nagaraja and Sylvie Rimsky
01:50 pm – 02:20 pm

IL 7: V. Nagaraja, JNCASR, Bangalore
Topology-transcription nexus : genome-wide recruitment and

action of topoisomerases probed by their Achilles’s heel
02:20 pm – 02:50 pm

IL 8: Sylvie Rimsky, Collège de France, Paris

Bacterial-Chromatin Structural Proteins Regulate the Bimodal Expression of the Locus of Enterocyte Effacement (LEE) Pathogenicity Island in Enteropathogenic Escherichia coli

02:50 pm – 03:20 pm

IL 9: Anjana Badrinarayanan, NCBS, Bangalore

  Regulation of DNA double-strand break repair in bacteria
03:20 pm – 03:50 pm

IL 10: D. Narasimha Rao, IISc, Bangalore

MutS2-mediated regulation of genetic recombination in Helicobacter pylori
03:50 pm – 04:10 pm COFFEE BREAK
03:50 pm – 05:20 pm     Session IV:    POSTER PRESENTATION I (Odd numbers)
05:20 pm – 07:30 pm     Session V: DNA damage sensing, signalling and therapeutics
  Chairperson: Jean-Pierre de Villartay and Anupam Chatterjee
05:20 pm – 05:50 pm

IL 11: Muralidhar L Hegde, HMRI, Houston

  New Mechanism of Genome Repair Inhibition Involving RNA binding proteins TDP-43 and FUS in motor neuron disease
05:50 pm – 06:20 pm

IL 12: Mayurika Lahiri, IISER, Pune

DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage
06:20 pm – 06:50 pm

IL 13: Anupam Chatterjee, NEHU, Shillong

Induction of precocious anaphase and chromosome instability, elevated expression of Securin gene and association of GSTP1 I105V polymorphism in areca nut-induced oral carcinogenesis
06:50 pm – 07:10 pm

SP 3: Bibha Choudhary, IBAB, Bangalore

SCR7, a ligase IV inhibitor, induces apoptosis in cancer cells by modulating DNA damage response miRNAs
07:10 pm – 07:30 pm

SP 4: Dibyendu Banerjee, CDRI, Lucknow

Compensatory role of human DNA ligase I during topoisomerase I inhibition in colorectal cancer cells
07:30 pm – 07:50 pm Special Lecture
  Chairperson: D. Narasimha Rao

Srini Kaveri, CNRS, New Delhi

CNRS Bureau in India: a gateway for scientific collaboration with France



DAY 2: Tuesday, 5 December 2017

07:00 am – 08:15 am


08:30 am – 10:20 am 

Session VI: Regulation of meiotic crossover


Chairperson: Raphaël Mercier and K.T. Nishant

08:30 am – 09:00 am

IL 14: Raphaël Mercier, IJPB INRA, Versailles
What limits meiotic crossovers?

09:00 am – 09:30 am

IL 15: K.T. Nishant, IISER, Thiruvananthapuram
The baker’s yeast Msh4-Msh5 complex binds away from the chromosome axis to promote meiotic crossing over

09:30 am – 10:00 am

IL 16: Valérie Borde, Institut Curie, Paris
Stabilizing and protecting meiotic recombination intermediates for a safe trip to crossover

10:00 am – 10:20 am

SP 5: Mridula Nambiar, Fred Hutch Cancer Res Ctr, Seattle
Centromere-specific cohesin complex prevents lethal crossovers during meiosis

10:20 am – 10:40 am


10:40 am – 01:00 pm    

Session VII: DNA replication and recombination


Chairperson: Karine Dubrana and Deepak Nair

10:40 am – 11:10 am

IL 17: Karine Dubrana, IRCM, Fontenay aux Roses
Recombination efficiency between subtelomeres is regulated by physical distance, DSB resection and chromatin status

11:10 am – 11:40 am

IL 18: Narottam Acharya, ILS, Bhubaneswar
Non-TLS Function of a TLS DNA Polymerase- eta (h)

11:40 am – 12:10 pm

IL 19: Deepak Nair, RCB, Delhi
Structural Studies on Molecular Determinants of Genomic Integrity & Plasticity

12:10 pm – 12:40 pm

IL 20: Ganesh Nagaraju, IISc, Bangalore
RAD51C/XRCC3 facilitates mitochondrial DNA replication to maintain integrity of the mitochondrial genome

12:40 pm – 01:00 pm

SP 6: Madhusoodanan UK, IFOM, Milan
Regulation of recombination at sites of stalled replication

01:00 pm – 01:40 pm


01:40 pm – 04:10 pm    

Session VIII: Repair pathways in maintaining genome integrity


Chairperson: Patrick Revy and Sagar Sengupta

01:40 pm – 02:10 pm

IL 21: Sagar Sengupta, NII, New Delhi
MRN complex-dependent recruitment of ubiquitylated BLM helicase to double strand breaks negatively regulates DNA repair pathways

02:10 pm – 02:40 pm

IL 22: Patrick Revy, INSERM, Paris
A RAD50 separation-of-function mutation that confers DNA repair defect without affecting ATM-dependent DNA damage response identified in a patient with bone marrow failure and microcephaly                                              

02:40 pm – 03:10 pm

IL  23: Parimal Das, BHU, Varanasi
TFE3 (Xp11.2) translocation: Destabilising genomic integrity and renal cell carcinoma pathogenesis

03:10 pm – 03:30 pm

SP 7: Kundan Sengupta, IISER, Pune
Genome plasticity in cells on softer matrices

03:30 pm – 03:50 pm

SP 8: Mahadesh Prasad, UoM, Mysore
Monoallelic Expression of Ebf1 results in Increased DNA damage in Mouse B- lineage Progenitors

03:50 pm – 04:00 pm

Technical Lecture 1


Gopalakrishna Ramaswamy, Founder and CEO, theraCUES Innovations Pvt Ltd, Bangalore
Enabling Genome Plasticity research through leading edge technologies

04:00 pm – 04:10 pm

Technical Lecture 2


Santosh Gonwar, Product manager, JJ Biotek, India

New technology in preservation, incubation and DNA analysis

04:10 pm – 04:30 pm


04:10 pm – 5:30 pm      

Session IX: POSTER PRESENTATION II (Even numbers)

05:30 pm – 07:30 pm    

Session X:  Studies on genomic integrity and plasticity                                 


Chairperson: Jean-Baptiste Charbonnier and Raphael Guerois

05:30 pm – 06:00 pm

IL 24: Imran Siddiqi, CCMB, Hyderabad

Regulation of DNA Damage Repair in Plants

06:00 pm – 06:30 pm

IL 24: Mrinal Kanti Bhattacharyya, UoH, Hyderabad
DNA Double Strand Break Repair Mechanism: the Achilles Heel of Malaria Parasites

06:30 pm – 07:00 pm

IL 25: Raphael Guerois, I2BC, CEA Saclay
Modelling and design of protein interactions involved in genome integrity pathways

07:00 pm – 07:30 pm

IL 26: Jean-Baptiste Charbonnier, I2BC, CEA Saclay
Structural Biology of DNA repair complexes involved in DSB repair and meiosis

07:30 pm – 07:40 pm


07: 45 pm onwards